How does LOME work?

1. Infections begin when mosquitoes probe prior to blood feeding. LOME defines the function probeHost(ixH, spz, t, x, y, MosqPf);

ixH :: the index of the host being probed spz :: the mosquitoes sporozoite status (TRUE/FALSE) t, x, y :: the time and location of the bite MosqPf :: an object with information about Pf in the mosquito

The probeHost algorithm does the following

1. counts the bite (hbr)
   
2. if (spz == TRUE)
   • counts the infectious bite (eir)
   • draws a random # of sporozoites passed
   • determines survival of sporozoites from non-specific responses
   • identify the clonal recombinant of each SPZ
   • get the SPZ PE types
   • reduce # for type-specific PE immunity
   • count nSPZ reaching the liver
   • reduce # for type-specific liver immunity
3. if(nSPZ>0) add each spz clone to the eventQ and pedigree

2. The human object activates an infection from the eventQ

1. create the time course for the infection & (possibly) queue fever

3. Modifies the time course of other infections

4. Updating the model requires
5. updateImmunity
6. updateInfection

7. OPTIONAL: updateHistory

8. When a mosquito takes a bloodmeal
9. draw a random number to infect mosquito
10. If infected
    1. how many oocysts form?
       
    2. return the PfID of each parent

NOTES:

1. Get the tent function working
2. Get prInfectMosquito working (generic)

3. Get infectMosquito working

4. Mosquito bite to bloodstream infection

5. Asexual blood stage infection to gametocytes

1. fever & disease
2. immunity (affecting future infections)
3. gametocytogenesis

3. Mature gametocytes to mosquito infection

Three models to get running:

1. The basic queueing model, with the PfTentTimeCourse 1a. with fever 1b. with treatment